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Cross-Trait Genomic and Proteomic Analyses Identify Shared Risk Loci and Therapeutic Targets for Type 2 Diabetes and Coronary Artery Disease

2026-06-18

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<title>Abstract</title> <p> <bold>Background:</bold> Type 2 diabetes (T2D) and coronary artery disease (CAD) frequently coexist, yet their shared genetic basis and molecular mechanisms remain poorly understood. <bold>Methods:</bold> We integrated cross-trait genomic analyses, transcriptomics, proteomics, and cell-type-stratified analyses to systematically characterize the shared genetic architecture of T2D an...

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Literature Corpus work
b15e70a8-39be-582f-a272-05b9191ad4a4
DOI
10.21203/rs.3.rs-9293169/v1
Open publication

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Cross-Trait Genomic and Proteomic Analyses Identify Shared Risk Loci and Therapeutic Targets for Type 2 Diabetes and Coronary Artery DiseaseDOI 10.21203/rs.3.rs-9293169/v1
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