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Article

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders.

Communications biology - 18 Jul 2022

Adewuyi Emmanuel O, O'Brien Eleanor K, Nyholt Dale R, Porter Tenielle, Laws Simon M

Abstract excerpt

Consistent with the concept of the gut-brain phenomenon, observational studies suggest a relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; however, their underlying mechanisms remain unclear. Here, we analyse several genome-wide association studies (GWAS) summary statistics (N = 34,652-456,327), to assess the relationship of AD with GIT disorders. Findings reveal a positive...

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Identifiers

PMID: 35851147
DOI: 10.1038/s42003-022-03607-2
PMCID: PMC9293965

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