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Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome.

Acta neuropathologica - 6 Aug 2024

Alldred Melissa J, Pidikiti Harshitha, Ibrahim Kyrillos W, Lee Sang Han, Heguy Adriana, Hoffman Gabriel E, Roussos Panos, Wisniewski Thomas, Wegiel Jerzy, Stutzmann Grace E, Mufson Elliott J, Ginsberg Stephen D

Abstract excerpt

We elucidated the molecular fingerprint of vulnerable excitatory neurons within select cortical lamina of individuals with Down syndrome (DS) for mechanistic understanding and therapeutic potential that also informs Alzheimer's disease (AD) pathophysiology. Frontal cortex (BA9) layer III (L3) and layer V (L5) pyramidal neurons were microisolated from postmortem human DS and age- and sex-matched controls (CTR) to...

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PMID: 39105932
DOI: 10.1007/s00401-024-02768-0
PMCID: PMC11578391

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