Article

Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutations

2026-05-29

Abstract excerpt

How the cutaneous microenvironment influences early melanomagenesis is poorly understood. Here, we assessed the effects of three immune perturbations on premalignant melanocyte expansion in an autochthonous mouse model of disease. Depletion of regulatory T (T reg ) cells markedly accelerated melanoproliferation, an unexpected phenotype that was associated with monocyte and macrophage infiltration, the production...

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Identifiers and source

Literature Corpus work: f04c165b-dda4-50ea-a2cd-39038f97f5c6
DOI: 10.64898/2026.05.27.728115

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