Article

Longitudinal multimodal characterization of radiation dermatitis in the C57BL/6J mouse model

2025-11-10

Abstract excerpt

Radiation dermatitis (RD) is a frequent and therapy-limiting toxicity of cancer radiotherapy, yet its mechanistic basis remains poorly understood. To address the need for quantitative, mechanistic insight, we developed a longitudinal C57BL/6J mouse model integrating clinical grading, non-invasive biophysical (“mesoscopic”) measurements, histopathology, and bulk transcriptomics. This controlled design enabled pseud...

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Literature Corpus work: e46cd948-c21f-5a01-9966-f853ecabf3d7
DOI: 10.1101/2025.11.08.687376

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