Article

Remodelling of the skin stromal niche during melanoma transformation

2026-04-16

Abstract excerpt

<title>Abstract</title> <p>Skin melanocytes are repeatedly exposed to ultraviolet (UV) radiation making them susceptible to somatic mutations1. Thus 80% of benign melanocytic nevi have somatic mutations in the MAPK pathway genes most commonly affecting the BRAF and NRAS oncogenes 1,2. However, far from all benign nevi transforms into an invasive melanoma. Interaction between mutant melanocytes and their skin micr...

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Literature Corpus work: ff7dc15e-59e2-5864-982c-575362bc6e43
DOI: 10.21203/rs.3.rs-9292915/v1

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