Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic UV radiation-induced RORγt+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion.

Proceedings of the National Academy of Sciences of the United States of America - 14 Sept 2021

Lewis Julia M, Monico Patrick F, Mirza Fatima N, Xu Suzanne, Yumeen Sara, Turban Jack L, Galan Anjela, Girardi Michael

Abstract excerpt

Chronic ultraviolet (UV) radiation exposure is the greatest risk factor for cutaneous squamous cell carcinoma (cSCC) development, and compromised immunity accelerates this risk. Having previously identified that epidermal Langerhans cells (LC) facilitate the expansion of UV-induced mutant keratinocytes (KC), we sought to more fully elucidate the immune pathways critical to cutaneous carcinogenesis and to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Interleukin-22

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukins

Share to Keratinocytes

Share to Langerhans Cells

Share to Lymphocytes

Share to Nuclear Receptor Subfamily 1, Group F, Member 3

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 34504008
DOI: 10.1073/pnas.2016963118
PMCID: PMC8449378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic UV radiation-induced RORγt+ IL-22-producing lymphoid cells are associated with mutant KC clonal expansion.PMID 34504008Read ↗

A Perspective on the Interplay of Ultraviolet-Radiation, Skin Microbiome and Skin Resident Memory TCRαβ+ CellsSemantic proximity Read ↗

Inflammasome Activation in Cutaneous Squamous Cell CarcinomaSemantic proximity Read ↗

UVB-induced melanocyte proliferation in neonatal mice driven by CCR2-independent recruitment of Ly6c(low)MHCII(hi) macrophages.Semantic proximity Read ↗

A Spatially Coordinated Keratinocyte-Fibroblast Circuit Recruits MMP9 <sup>+</sup> Myeloid Cells to Drive IFN-I-Driven Inflammation in Photosensitive AutoimmunitySemantic proximity Read ↗

Keratinocyte Carcinomas: Current Concepts and Future Research PrioritiesSemantic proximity Read ↗

Cutaneous inflammation accelerates the premalignant expansion of melanocytes bearing oncogenic mutationsSemantic proximity Read ↗

TGFβ Signaling in Photoaging and UV-Induced Skin Cancer.Semantic proximity Read ↗

A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivitySemantic proximity Read ↗

Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentationSemantic proximity Read ↗

Biomarkers of UVB radiation-related senescent fibroblastsSemantic proximity Read ↗

Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the DermisSemantic proximity Read ↗

TLR4 in skin cancer: From molecular mechanisms to clinical interventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.