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Article

Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis.

Cancer research - 1 Sept 2018

Shabaneh Tamer B, Molodtsov Aleksey K, Steinberg Shannon M, Zhang Peisheng, Torres Gretel M, Mohamed Gadisti A, Boni Andrea, Curiel Tyler J, Angeles Christina V, Turk Mary Jo

Abstract excerpt

Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role in restraining immunosurveillance during tumorigenesis. Here, we employ an inducible autochthonous model of melanoma to investigate the earliest Treg and CD8 effector T-cell responses during oncogene-driven tumorigenesis. Induction of oncogenic BRAFV600E and loss of Pten in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30026331
DOI: 10.1158/0008-5472.CAN-18-0365
PMCID: PMC6319620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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