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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

10 Dec 2021

Abstract excerpt

A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor. To identify new genes involved in the cellular uptake of LDL, we developed a novel whole-genome clustered regularly interspaced short palindromic repeat-Cas9 KO screen in HepG2 cells. We...

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PMID: 34902367
DOI: 10.1016/j.jlr.2021.100160

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