Article

Transgelin: A New Gene Involved in LDL Endocytosis Identified by a Genome-wide CRISPR-Cas9 Screen

2020-12-24

Abstract excerpt

To identify new genes involved in the cellular uptake of low-density lipoprotein (LDL), we applied a novel whole genome CRISPR/Cas9 knockout-screen on HepG2 cell lines. We identified TAGLN (transgelin), an actin-binding protein, as a new gene involved in LDL endocytosis. In silico validation demonstrated that genetically predicted differences in expression of TAGLN in human populations were associated with plas...

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Literature Corpus work: f29304c6-008e-50c4-8c9c-ee39713eb0cb
DOI: 10.1101/2020.12.23.424170

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