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Article

Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans.

Cell metabolism - 5 Dec 2023

Pan Chuyue, Liu Jun, Gao Yingsheng, Yang Maohui, Hu Haiyang, Liu Chang, Qian Minyi, Yuan Hai-Yang, Yang Song, Zheng Ming-Hua, Wang Lirui

Abstract excerpt

Metabolic dysfunction-associated steatohepatitis (MASH) is a leading risk factor for liver cirrhosis and hepatocellular carcinoma. Here, we report that CHRNA4, a subunit of nicotinic acetylcholine receptors (nAChRs), is an accelerator of MASH progression. CHRNA4 also mediates the MASH-promotive effects induced by smoking. Chrna4 was expressed specifically in hepatocytes and exhibited increased levels in mice and...

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Identifiers

PMID: 38056431
DOI: 10.1016/j.cmet.2023.10.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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