Article
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes.
The Journal of biological chemistry - 1 Dec 2021
Dall Morten, Hassing Anna S, Niu Lili, Nielsen Thomas S, Ingerslev Lars R, Sulek Karolina, Trammell Samuel A J, Gillum Matthew P, Barrès Romain, Larsen Steen, Poulsen Steen S, Mann Matthias, Ørskov Cathrine, Treebak Jonas T
Abstract excerpt
Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD+. As low hepatic NAD+ levels have been linked to the development of nonalcoholic fatty liver disease, we hypothesized that ablation of hepatic Nampt would affect susceptibility to liver injury in response to diet-induced metabolic stress. Following 3 weeks on a low-methionine and choline-free 60% high-fat diet, hepatocyte-specific Nampt...
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