ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Abstract excerpt

Background & Aims Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD + ) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD), primarily expressed in the liver and kidney, acts as a modulator of de novo NAD + synthesis. Boosting NAD +...

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