Article
Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist
9 Oct 2019
Abstract excerpt
Abstract The inflammasomes play critical roles in numerous pathological conditions largely through IL-1β and/or IL-18. However, additional effectors have been implied from multiple studies. In this study, through two independent mass spectrometry–based secretome screening approaches, we identified galectin-3 as an effector protein of the NLRP3 inflammasome. Although the activation of AIM2 or NLRC4 inflammasome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.