Article

Perturbing O-GlcNAcase Modulates the Expression and Distribution of Galectin-3

2026-01-16

Abstract excerpt

Galectin-3 (Gal-3) is a β-galactoside-binding lectin implicated in metabolic inflammation, cardiovascular and renal dysfunction, neurodegenerative disorders, and obesity-related pathologies. Although Gal-3 is recognized as a clinically relevant biomarker, the mechanisms controlling its tissue expression and circulating abundance remain poorly defined. O-GlcNAcase (Oga; encoded by Mgea5), the enzyme that removes O-...

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Literature Corpus work: 1a8f127c-a154-5402-aa2c-e8a5a7db3787
DOI: 10.20944/preprints202601.1208.v1

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