A Novel MiRNA Detection System Combining TWJ-SDA, Multistep L-TEAM, and CRISPR-Cas3

Abstract excerpt

MicroRNAs (miRNAs) serve critical regulatory roles in gene expression and are valuable biomarkers for early disease detection. However, their inherent low concentration in biological fluids poses significant detection challenges. Although traditional methods like real-time quantitative PCR (RT-qPCR) are highly sensitive, they require thermal cycling, limiting their application in point-of-care testing (POCT). Here...

Topics

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• Biosensing Techniques
• COVID-19
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Hepatitis B virus
• Molecular Diagnostic Techniques
• Nucleic Acid Amplification Techniques
• RNA, Viral

Identifiers and source

Literature Corpus work

f0033d6c-2d73-586a-b0aa-0e29f9f5879a

DOI

10.1101/2025.09.25.678453