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SATCAS: A CRISPR/Cas13a-based simultaneous amplification and testing platform for one-pot RNA detection and SNPs distinguish in clinical diagnosis.

Biosensors & bioelectronics - 1 Nov 2024

Wang Ting, Bai Linlin, Wang Guoling, Han Jingli, Wu Lixin, Chen Xuanzhong, Zhang Hongyu, Feng Jia, Wang Yongming, Wang Rui, Zhang Xiaohui

Abstract excerpt

The clinical diagnosis of pathogen infectious diseases increasingly requires sensitive and rapid RNA detection technologies. The RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/Cas13a system has shown immense potential in molecular diagnostics due to its trans-cleavage activity. However, most Cas13a-based detection methods require an amplicon transcription step, and the multi-step...

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PMID: 39116631
DOI: 10.1016/j.bios.2024.116636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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