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Article

Mitochondrial translocation of APE1 relies on the MIA pathway.

Nucleic acids research - 23 Jun 2015

Barchiesi Arianna, Wasilewski Michal, Chacinska Agnieszka, Tell Gianluca, Vascotto Carlo

Abstract excerpt

APE1 is a multifunctional protein with a fundamental role in repairing nuclear and mitochondrial DNA lesions caused by oxidative and alkylating agents. Unfortunately, comprehensions of the mechanisms regulating APE1 intracellular trafficking are still fragmentary and contrasting. Recent data demonstrate that APE1 interacts with the mitochondrial import and assembly protein Mia40 suggesting the involvement of a...

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Share to DNA Damage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to Mitochondrial Membrane Transport Proteins

Share to Mitochondrial Precursor Protein Import Complex Proteins

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Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 25956655
DOI: 10.1093/nar/gkv433
PMCID: PMC4477663

Genes

MIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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