Article

Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN

2022-09-03

Abstract excerpt

The heterotetrameric human transfer RNA (tRNA) splicing endonuclease (TSEN) catalyzes the excision of intronic sequences from precursor tRNAs (pre-tRNAs) 1 . Mutations in TSEN and its associated RNA kinase CLP1 are linked to the neurodegenerative disease pontocerebellar hypoplasia (PCH) 2–8 . The three-dimensional (3D) assembly of TSEN/CLP1, the mechanism of substrate recognition, and the molecular details of PC...

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Literature Corpus work: a8965f73-c5e0-5c94-8fdc-e16231a0e500
DOI: 10.1101/2022.09.03.506465

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