Article
Snf1 AMPK positively regulates ER-phagy via expression control of Atg39 autophagy receptor in yeast ER stress response.
PLoS genetics - 1 Sept 2020
Mizuno Tomoaki, Muroi Kei, Irie Kenji
Abstract excerpt
Autophagy is a fundamental process responsible for degradation and recycling of intracellular contents. In the budding yeast, non-selective macroautophagy and microautophagy of the endoplasmic reticulum (ER) are caused by ER stress, the circumstance where aberrant proteins accumulate in the ER. The more recent study showed that protein aggregation in the ER initiates ER-selective macroautophagy, referred to as...
Topics
- Autophagy
- Autophagy-Related Proteins
- Endoplasmic Reticulum Stress
- Gene Expression Regulation, Fungal
- Microorganisms, Genetically-Modified
- Mitophagy
- Mutation
- Phosphorylation
- Promoter Regions, Genetic
- Protein Serine-Threonine Kinases
- Receptors, Cytoplasmic and Nuclear
- Repressor Proteins
- Saccharomyces cerevisiae