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Article

A transport-independent role for SLC25A12 in mitochondrial stress signalling.

Nature cell biology - 1 Jul 2026

Jiang Liu, Li Lan, Guan Jialiang, Liu Ying

Abstract excerpt

Mitochondria are central hubs for energy production and cellular adaptation to stress. When mitochondria are damaged, cells activate protective signalling pathways to restore homeostasis and ensure survival. One such pathway, known as the integrated stress response (ISR), reduces overall protein synthesis while enhancing the production of stress-responsive proteins. The mitochondrial carriers SLC25A12 and...

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Source

Identifiers

PMID: 42203926
DOI: 10.1038/s41556-026-01973-1

Genes

SLC25A12
OMA1
SLC25A13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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