Article

Mitochondrial protein import clogging as a mechanism of disease

2022-09-21

Abstract excerpt

Mitochondrial biogenesis requires the import of >1,000 mitochondrial preproteins from the cytosol. Most studies on mitochondrial protein import are focused on the core import machinery. Whether and how the biophysical properties of substrate preproteins affect overall import efficiency is underexplored. Here, we show that protein traffic into mitochondria is disrupted by amino acid substitutions in a single substr...

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Literature Corpus work: f2c06152-5d94-5f40-b9ac-0cb578374f6b
DOI: 10.1101/2022.09.20.508789

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