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Article

Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors

7 Feb 2021

Abstract excerpt

Helper T (Th) and regulatory T (Treg) cell differentiation programs promote the eradication of pathogens, while minimizing adverse immune reactions. Here, we found that Nr4a family of nuclear receptors supports Treg cell induction and represses Th1 and Th2 cell differentiation from naive CD4 + T cells. Nr4a factors are transiently induced in CD4 + T cells immediately after antigen stimulation, thereby mediating...

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PMID: 33665581
DOI: 10.1016/j.isci.2021.102166

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