Article

Neuropilin-2 functions as a co-inhibitory receptor to regulate antigen-induced inflammation and allograft rejection

2025-04-23

Abstract excerpt

Co-inhibitory receptors function as central modulators of the immune response to resolve T effector activation and/or to sustain immune homeostasis. Here, using humanized SCID mice, we found that NRP2 is inducible on late effector and exhausted subsets of human CD4 + T cells and that it is co-expressed with established co-inhibitory molecules including PD-1, CTLA4, TIGIT, LAG3 and TIM3. In murine models, we also...

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Identifiers and source

Literature Corpus work: 9174fa3a-de57-5aa5-9ed6-3c1fbcdca08a
DOI: 10.1101/2025.04.17.648233

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