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Article

Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets

11 Feb 2017

Abstract excerpt

NKT cells represent a small subset of glycolipid-recognizing T cells that are heavily implicated in human allergic, autoimmune, and malignant diseases. In the thymus, precursor cells recognize self-glycolipids by virtue of their semi-invariant TCR, which triggers NKT cell lineage commitment and maturation. During their development, NKT cells are polarized into the NKT1, NKT2, and NKT17 subsets, defined through...

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PMID: 28188245
DOI: 10.4049/jimmunol.1601732

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