Article

Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression

2021-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identified a unique B cell population in the synovium characterized by co-expression of a family of orphan nuclear receptors, NR4A1 (also known as NUR77), NR4A2 (NURR1) and NR4A3 (NOR1), that is highly enriched a...

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Literature Corpus work: 710a8083-c863-5181-ba02-5ea602bb0ff9
DOI: 10.1101/2021.05.14.443150

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