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A Critical Re-evaluation of the Somatic Mutation Theory (SMT) Conceptual and Quantitative Limits of the Cell-Centric Paradigm

2025-10-17

Abstract excerpt

The Somatic Mutation Theory (SMT) frames cancer as a stochastic process driven by the accumulation of random mutations in somatic cells. Using a Poisson–Erlang waiting-time model, we test whether empirical mutation rates and cell-division frequencies permit such multi-hit carcinogenesis within biologically realistic timescales. Even under optimistic assumptions, expected waiting times exceed progenitor-cell lifesp...

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Literature Corpus work
45c0b089-9ac1-5c33-8850-bf62baf3c29a
DOI
10.1101/2025.10.17.683033
Open publication

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A Critical Re-evaluation of the Somatic Mutation Theory (SMT) Conceptual and Quantitative Limits of the Cell-Centric ParadigmDOI 10.1101/2025.10.17.683033
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