Somatic mutations impose an entropic upper bound on human lifespan

Abstract excerpt

Somatic mutations accumulate with age and can cause cell death, but their quantitative contribution to limiting human lifespan remains unclear. We developed an incremental modeling framework that progressively incorporates factors contributing to aging into a model of population survival dynamics, which we used to estimate lifespan limits if all aging hallmarks were eliminated except somatic mutations. Our analysi...

Topics

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• Age Factors
• Aging
• Carcinogenesis
• Exome Sequencing
• Genomic Instability
• Longevity
• Mutation
• Phenotype

Identifiers and source

Literature Corpus work

24d2e7b2-534c-517b-b094-ee71334fa075

DOI

10.1101/2025.11.23.689982