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Article

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype.

Communications biology - 28 Jun 2024

Zvirblyte Justina, Nainys Juozas, Juzenas Simonas, Goda Karolis, Kubiliute Raimonda, Dasevicius Darius, Kincius Marius, Ulys Albertas, Jarmalaite Sonata, Mazutis Linas

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the disease contributes to late-stage diagnoses and poor survival. Highly vascularized and immune infiltrated microenvironment are prominent features of ccRCC, yet the interplay between vasculature and immune cells, disease progression and response to therapy remains...

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Share to Carcinoma, Renal Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38942917
DOI: 10.1038/s42003-024-06478-x
PMCID: PMC11213875

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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