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Article

Distinct genomic, microenvironmental, and nephron signatures in VHL kidney cysts and tumors.

Scientific reports - 9 Jan 2026

Rowe Isaline, Corea Francesca, Pipitone Giovanni B, Scotti Giulia M, Lucianò Roberta, Sant'Angelo Miriam, Tenace Nazario P, Franco Irene, Ferrara Anna Maria, Doglioni Claudio, Ponzoni Maurilio, De Cobelli Francesco, Montorsi Francesco, Capitanio Umberto, Carrera Paola, Larcher Alessandro, Salonia Andrea

Abstract excerpt

Patients with von Hippel-Lindau (VHL) disease develop multiple distinct kidney cysts and clear cell renal cell carcinomas (ccRCCs) throughout their lifetime. Although cysts are typically considered precursors of ccRCC, no molecular evidence of cysts to tumor progression was provided to date, due to the lack of an accurate molecular characterization of these lesions. We performed a comprehensive molecular...

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Share to Carcinoma, Renal Cell
Share to Kidney Diseases, Cystic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41513925
DOI: 10.1038/s41598-025-34381-w
PMCID: PMC12864757

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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