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Integrative transcriptomic profiling of the phosphatome identifies DUSP15 as a chromophobe renal cell carcinoma–selective epithelial biomarker associated with an immune-metabolic tumour state

2025-11-17

Abstract excerpt

Chromophobe renal cell carcinoma (chRCC) lacks robust molecular biomarkers and actionable therapeutic targets. Here, 265 protein-coding phosphatases were systematically interrogated using pan-cancer transcriptomic profiles from The Cancer Genome Atlas, 10 independent Gene Expression Omnibus cohorts, pathway and immune analyses, and two independent single-cell RNA-sequencing datasets. DUSP15 emerged as the most ch...

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Literature Corpus work
233a1cd1-a968-5b47-8c61-d20ff011a771
DOI
10.1101/2025.11.15.688610
Open publication

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Integrative transcriptomic profiling of the phosphatome identifies DUSP15 as a chromophobe renal cell carcinoma–selective epithelial biomarker associated with an immune-metabolic tumour stateDOI 10.1101/2025.11.15.688610
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