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Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

1 Oct 2019

Abstract excerpt

To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC), we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and phosphoproteomic characterization of treatment-naive ccRCC and paired normal adjacent tissue samples. Genomic analyses identified a distinct molecular subgroup associated with genomic instability. Integration of proteogenomic...

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PMID: 31675502
DOI: 10.1016/j.cell.2019.10.007

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