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Article

Role of telomerase in the tumour microenvironment

4 Dec 2019

Abstract excerpt

Telomeres are specialized genomic structures that protect chromosomal ends to maintain genomic stability. Telomeric length is primarily regulated by the telomerase complex, essentially consisting of an RNA template (TERC), an enzymatic subunit (telomerase reverse transcriptase, TERT). In humans, telomerase activity is repressed during embryonic differentiation and is absent in most somatic cells. However, it is...

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PMID: 31799699
DOI: 10.1111/1440-1681.13223

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