Article

Targeting CXCR4–JNK/c-Jun–CTSB Signaling Axis Attenuates Silicosis Fibrosis in Mice

2026-02-02

Abstract excerpt

<title>Abstract</title> <p> Silicosis is a severe occupational lung disease characterized by progressive and irreversible pulmonary fibrosis. CXCR4 (C-X-C chemokine receptor type 4) has been implicated in the pathogenesis of silicosis, yet the specific molecular mechanism through which CXCR4 signaling promotes fibrotic progression remain unclear. In this study, we systematically investigated the role of CXCR4 in...

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Literature Corpus work: ef7d1491-4ab6-503c-a5d8-351cfcc0b38f
DOI: 10.21203/rs.3.rs-8497777/v1

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