Article

Targeting acid sphingomyelinase/ceramide/S1P ameliorates silica-induced pulmonary fibrosis through Hippo/YAP signaling pathway in mice

2025-07-30

Abstract excerpt

<title>Abstract</title> <p>Silicosis is irreversible lung disease caused by exposure to dust-containing silica particles. Our study aims to explore the potential effects of acid sphingomyelinase (aSMase), ceramide (Cer) and sphingosine-1-phosphate (S1P) on silica-induced pulmonary fibrosis. We also explored the expression of the downstream signaling pathway of Hippo/YAP. The high expression of SMPD1 which encodes...

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Literature Corpus work: 4d14ad01-65d7-528c-8193-b8e523a9a887
DOI: 10.21203/rs.3.rs-7052670/v1

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