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CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis

2025-04-16

Abstract excerpt

This study investigates the role of the chemokine CXCL16 and its receptor, CXCR6, in post-traumatic osteoarthritis (PTOA) and joint nociception, highlighting the potential of targeting the CXCL16-CXCR6 axis for therapeutically managing joint inflammation and pain. Following joint injury in mice, the CXCL16-CXCR6 signaling axis is activated in synovium, driven by synovial fibroblasts and macrophages. Human OA synov...

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Identifiers and source

Literature Corpus work
b202d416-f4f4-524b-b1ad-4fd1428658df
DOI
10.1101/2025.04.10.647297
Open publication

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CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritisDOI 10.1101/2025.04.10.647297
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