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Crystalline silica-induced recruitment and immuno-imbalance of CD4 + Tissue Resident Memory T cells promote the progression of silicosis.

2023-10-19

Abstract excerpt

Background: Occupational crystalline silica (CS) particle exposure leads to silicosis. The burden of CS-associated disease remains high, and treatment options are limited due to vague mechanisms. CD4 + tissue-resident memory T cells (T RM ) accumulate in the lung responded to CS particles, mediating the pathogenesis of silicosis. <h4>Methods:</h4> Based on silicosis murine model by single intratracheal instillat...

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Literature Corpus work
8d331279-b618-500d-ba83-036bd428ab99
DOI
10.22541/au.169769380.04104081/v1
Open publication

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