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Integrative transcriptomic and proteomic analysis reveals mechanisms of silica-induced pulmonary fibrosis in rats

7 Jan 2022

Abstract excerpt

BACKGROUND: Silicosis is a systemic disease characterized by persistent inflammation and incurable pulmonary fibrosis. Although great effort has been made to understand the pathogenesis of the disease, molecular mechanism underlying silicosis is not fully elucidated. This study was aimed to explore proteomic and transcriptomic changes in rat model of silicosis. METHODS: Twenty male Wistar rats were randomly...

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Share to Aluminum toxicity and tolerance in plants and animals
Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 34991559
DOI: 10.1186/s12890-021-01807-w

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