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NR4A3 mediates Coal Dust Nanoparticle-induced Immunopathogenesis in Rheumatoid Arthritis

2026-08-18

Abstract excerpt

<title>Abstract</title> <p> Coal miners with chronic coal dust exposure have elevated rheumatoid arthritis (RA) risk, yet the molecular mechanisms underlying this association remain poorly understood. Here we identify the orphan nuclear receptor NR4A3 as a central mediator linking coal dust nanoparticles (CD-NPs) to RA immunopathogenesis. Intranasal exposure of adjuvant-induced arthritis rats to CD-NPs for three...

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Literature Corpus work
7a7c4188-2314-5054-8176-ae9d50dd09d1
DOI
10.21203/rs.3.rs-10711979/v1
Open publication

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NR4A3 mediates Coal Dust Nanoparticle-induced Immunopathogenesis in Rheumatoid ArthritisDOI 10.21203/rs.3.rs-10711979/v1
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