Article

A CRISPR-Cas9 screen reveals a role for WD repeat-containing protein 81 (WDR81) in the entry of late penetrating viruses

2021-09-27

Abstract excerpt

<h4>ABSTRACT</h4> Successful initiation of infection by many different viruses requires their uptake into the endosomal compartment. While some viruses exit this compartment early, others must reach the degradative, acidic environment of the late endosome. Mammalian orthoreovirus (reovirus) is one such late penetrating virus. To identify host factors that are important for reovirus infection, we performed a CRISP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef7a3408-80c8-5f3f-b2eb-d0477a1bff67
DOI: 10.1101/2021.09.26.461887

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A CRISPR-Cas9 screen reveals a role for WD repeat-containing protein 81 (WDR81) in the entry of late penetrating virusesDOI 10.1101/2021.09.26.461887Read

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasisSemantic proximity Read

WDR81 represses IKK mediated expression of pro-survival genes to regulate apoptosisSemantic proximity Read

Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infectionSemantic proximity Read

Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus ReplicationSemantic proximity Read

CRISPR screening of porcine sgRNA library identified host factors essential for Japanese encephalitis virus replicationSemantic proximity Read

The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71.Semantic proximity Read

CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replicationSemantic proximity Read

Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationSemantic proximity Read

Genome-Wide Screen Reveals Valosin-Containing Protein Requirement for Coronavirus Exit from EndosomesSemantic proximity Read

Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16Semantic proximity Read

DYRK1A is a multifunctional host factor that regulates coronavirus replication in a kinase-independent mannerSemantic proximity Read

VPS13A and VPS13C influence lipid droplet abundanceSemantic proximity Read