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DYRK1A is a multifunctional host factor that regulates coronavirus replication in a kinase-independent manner

15 Dec 2023

Abstract excerpt

ABSTRACT Coronaviruses (CoVs) pose a major threat to human and animal health worldwide, which complete viral replication by hijacking host factors. Identifying host factors essential for the viral life cycle can deepen our understanding of the mechanisms of virus–host interactions. Based on our previous genome-wide CRISPR screen of α-CoV transmissible gastroenteritis virus (TGEV), we identified the host factor...

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PMID: 38099687
DOI: 10.1128/jvi.01239-23

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