Article

Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis

2021-09-28

Abstract excerpt

Cholesterol homeostasis is required for the replication of many viruses, including Ebola virus, hepatitis C virus, and human immunodeficiency virus-1. Niemann-Pick C1 (NPC1) is an endosomal-lysosomal membrane protein involved in cholesterol trafficking from late endosomes and lysosomes to the endoplasmic reticulum. We identified NPC1 in CRISPR and RNA interference screens as a putative host factor for infection by...

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Literature Corpus work: 0e6a89b6-a196-550c-b710-18b839ea392a
DOI: 10.1101/2021.09.27.462002

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