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Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication

6 Dec 2021

Abstract excerpt

Emerging coronaviruses (CoVs) pose a severe threat to human and animal health worldwide. To identify host factors required for CoV infection, we used α-CoV transmissible gastroenteritis virus (TGEV) as a model for genome-scale CRISPR knockout (KO) screening. Transmembrane protein 41B (TMEM41B) was found to be a bona fide host factor involved in infection by CoV and three additional virus families. We found that...

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PMID: 34871328
DOI: 10.1371/journal.ppat.1010113

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