Article

A feed-forward loop between niche adenosine and Gzmk⁺ CD8 T cells propagates systemic inflammaging

2026-03-20

Abstract excerpt

The causal link between the aging microenvironment and T cell aging remains elusive. Here, we demonstrate that adenosine within aging tissues actively reprograms CD8+ T cells into a pro-aging Granzyme K + (Gzmk+) population. Mechanistically, senescent cells create an adenosine-rich niche via p16-dependent CD39 upregulation, triggering A2aR signaling to induce Gzmk + T cell differentiation. Once released, Gzmk pr...

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Literature Corpus work: ef74d19e-09eb-5ba2-9dc2-1f5d709e1100
DOI: 10.64898/2026.03.18.712515

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