Article

Pharmacological intervention targeting neuroimmune axis in the aging hypothalamus prevents age-associated physiological decline

2026-01-12

Abstract excerpt

Systemic physiological aging is largely driven by disrupted metabolic homeostasis, yet the central mechanisms of this metabolic dysfunction remain poorly defined. Here, we identify the hypothalamus as a critical hub driving systemic aging through neuroimmune-mediated mechanisms. Single-cell transcriptomic and immunohistochemical analyses revealed that aged hypothalami exhibit significant infiltration of CD8⁺ T lym...

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Literature Corpus work: 884b10d5-5c3e-5d52-b8a1-46b81b60f0dc
DOI: 10.64898/2026.01.12.698951

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