Article

CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis

2022-09-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in the US. This condition occurs in response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, the cause remains idiopathic. CD73 is a cell surface ecto-5’-nucleotidase that generates extracellular adenosine, which can contribute to resolution of inflamma...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d45eafc-e5bf-5732-9055-cbd76e7cacba
DOI: 10.1101/2022.09.17.508367

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD73 generated extracellular adenosine promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitisDOI 10.1101/2022.09.17.508367Read

Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosineSemantic proximity Read

Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia.Semantic proximity Read

CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependent mannerSemantic proximity Read

Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factorsSemantic proximity Read

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injurySemantic proximity Read

Heterozygous Spink1 c.194+2T>C mutation promotes chronic pancreatitis after acute attack in mice.Semantic proximity Read

Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute PancreatitisSemantic proximity Read

Single-nucleus transcriptomic analysis of pediatric pancreas reveals cellular heterogeneity and early neoplasia signatures during chronic pancreatitisSemantic proximity Read

Single-cell sequencing unveils distinct immune microenvironment with CCR6-CCL20 crosstalk in human chronic pancreatitisSemantic proximity Read

MicroRNAs in acute pancreatitis: From pathogenesis to novel diagnosis and therapySemantic proximity Read

The Role of MicroRNAs in Pancreatitis Development and ProgressionSemantic proximity Read

Molecular mechanisms of pancreatitis: current opinion.Semantic proximity Read