Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.

doi:10.1038/nm.4267

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Article

Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.

Nature medicine - 1 Feb 2017

Furman David, Chang Junlei, Lartigue Lydia, Bolen Christopher R, Haddad François, Gaudilliere Brice, Ganio Edward A, Fragiadakis Gabriela K, Spitzer Matthew H, Douchet Isabelle, Daburon Sophie, Moreau Jean-François, Nolan Garry P, Blanco Patrick, Déchanet-Merville Julie, Dekker Cornelia L, Jojic Vladimir, Kuo Calvin J, Davis Mark M, Faustin Benjamin

Abstract excerpt

Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the maturation of interleukin-1β (IL-1β). Here we find that the expression of specific inflammasome gene modules stratifies older...

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PMID: 28092664
DOI: 10.1038/nm.4267
PMCID: PMC5320935

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NLRC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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