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Article

Human induced pluripotent stem cell derived neurons as a model for Williams-Beuren syndrome.

Molecular brain - 24 Nov 2015

Khattak Shahryar, Brimble Elise, Zhang Wenbo, Zaslavsky Kirill, Strong Emma, Ross P Joel, Hendry Jason, Mital Seema, Salter Michael W, Osborne Lucy R, Ellis James

Abstract excerpt

BACKGROUND: Williams-Beuren Syndrome (WBS) is caused by the microdeletion of approximately 25 genes on chromosome 7q11.23, and is characterized by a spectrum of cognitive and behavioural features. RESULTS: We generated cortical neurons from a WBS individual and unaffected (WT) control by directed differentiation of induced pluripotent stem cells (iPSCs). Single cell mRNA analyses and immunostaining demonstrated...

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Identifiers

PMID: 26603386
DOI: 10.1186/s13041-015-0168-0
PMCID: PMC4657290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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