Article

Location of CD39+ T cell sub-populations within tumours predict differential outcomes in non-small cell lung cancer

2022-09-30

Abstract excerpt

An improved mechanistic understanding of immunosuppressive pathways in NSCLC is important to develop novel diagnostic and therapeutic approaches. Here, we reveal that the prognostic significance of the rate limiting ectonucleotidases in adenosine production CD39 and CD73 requires knowledge of cell type specific expression and localisation within tumours. In a cohort of early treatment naïve NSCLC patients, high st...

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Literature Corpus work: ef655e53-b722-5f5d-b770-0c44e2fe0ae2
DOI: 10.1101/2022.09.29.509921

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