Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions.

doi:10.1002/ijc.33131

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Article

Genetically driven CD39 expression shapes human tumor-infiltrating CD8+ T-cell functions.

International journal of cancer - 1 Nov 2020

Gallerano Daniela, Ciminati Selina, Grimaldi Alessio, Piconese Silvia, Cammarata Ilenia, Focaccetti Chiara, Pacella Ilenia, Accapezzato Daniele, Lancellotti Francesco, Sacco Luca, Caronna Roberto, Melaiu Ombretta, Fruci Doriana, D'Oria Valentina, Manzi Emy, Sagnotta Andrea, Parrino Chiara, Coletta Diego, Peruzzi Giovanna, Terenzi Valentina, Battisti Andrea, Cassoni Andrea, Fadda Maria Teresa, Brozzetti Stefania, Fazzi Katia, Grazi Gian Luca, Valentini Valentino, Chirletti Piero, Polimeni Antonella, Barnaba Vincenzo, Timperi Eleonora

Abstract excerpt

In our study, we investigated the role of CD39 on tumor-infiltrating CD8+ T lymphocytes (CD8+ TILs) in colorectal, head and neck and pancreatic cancers. Partially confirming recent observations correlating the CD39 expression with T-cell exhaustion, we demonstrated a divergent functional activity in CD39+ CD8+ TILs. On the one hand, CD39+ CD8+ TILs (as compared to their CD39- counterparts) produced significantly...

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PMID: 32483858
DOI: 10.1002/ijc.33131

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